45 During WSC, this mechanism triggers a modification in gait parameters, in particular by a reduction in velocity and frequency, and more so by an increase in double support time.
Nosaka et al. have studied Pdc2p structure [ 5] and propose that the interaction with Thi3p triggers a modification in Pdc2p configuration, which activates its transactivation function and the recruitment of the THI promoter.
Clearly the events of September have triggered a modification, a very deep change, maybe a sea change in the trans-Atlantic alliance.
One trigger is a modification of thiol residues in the Keap1 protein, typically as a result of an increase in ROS (Surh et al., 2008; Vargas and Johnson, 2009).
This study documents that temperature is a key signal able to trigger extensive modification in the GBS transcriptome.
We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling and simulation in predicting the domperidone (DOM) triggered pseudo-electrocardiogram modification in the presence of a CYP3A inhibitor, ketoconazole (KETO), using in vitro in vivo extrapolation.
Some reports demonstrated that changes in cell shape precede and trigger dramatic modifications in both gene expression and enzymatic function.
A scenario study at a defined spatial and temporal resolution is then used to explore how an IAS, as an exogenous driving force, may trigger modifications in the target environment.
Supporting this local sleep hypothesis, our results build on a growing body of evidence indicating that daytime waking experience can trigger regionally specific modifications in post-training sleep complexion [20] [22], and indicate that a similar local sleep change may also operate in the facilitation of offline consolidation and plasticity, leading to post-sleep memory improvements.
This leads to altered sensory inputs, which trigger a reorganization in sensorimotor processing leading to long-term central modification in movement planning and execution [ 19– 219.
