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O is the number of trials with significant p-value at a significance level of α with a two-sided t-test based on m Ei, s Ei, n Ei and m Ci, s Ci, n Ci.
O is the number of trials with significant p-value at a significance level α with a two-sided Fisher's exact test based on x Ei, x Ci, n Ei, n Ci.
The observed number is the total number of trials with significant p-values across the network.
Analysis with and without trials with significant baseline differences did not change any review conclusions.
The prevalence of these trials with significant results was high and unexpected.
CIRSE believes that only properly conducted trials with significant scientific rigor can solve this dilemma.
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In the vomitus settings, all participants succeeded in tracheal intubation with McL or McGRATH, while five failed in the AWS trial with significant difference (P = 0.003).
The combination of selumetinib and dacarbazine has demonstrated clinical activity in a phase II trial, with significant improvements in PFS observed in patients with BRAF mutation-positive advanced cutaneous or unknown melanoma receiving the combination versus dacarbazine alone [ 37].
AEOL 10150 is a novel, well-tolerated (as evidenced in initial clinical trials) antioxidant with significant protective and mitigative potential relative to acute radiation injuries, particularly acute pulmonary injury [ 108– 108].
Language bias has been demonstrated for randomised trials 58 studies with significant findings are more likely to be published in English-language journals and may also affect observation studies such as those included in this review.
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CEO of Professional Science Editing for Scientists @ prosciediting.com