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Data from five representative trials will be analysed.
The early 'automatic postural response' (which occurs in both stepping and grasping trials) will be analysed using centre-of-pressure measures and the latency and magnitude of the initial ankle-muscle activation (tibialis anterior, medial gastrocnemius).
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The results of the randomised clinical trial will be analysed according to the intention to treat principle.
Each trial will be analysed individually and the resulting analyses and trial data will be verified by trialists before inclusion in the EPOCH Collaboration database.
Each trial will be analysed individually, and the resulting analyses and trial data will be sent to the trialists for verification.
The trial will be analysed and reported according to the 'Consolidated Standard of Reporting Trials' (CONSORT), TIDieR and the International Conference on Harmonisation E9 guidelines.
Following completion of the multiple crossover part of the trial, the results of each n-of-1 trial will be analysed by the researchers and a report will be drafted for each patient individually (weeks 7 and 8).
The outcomes of this trial will be analysed in relation to the findings of Chang and colleagues 2 that prolonged MV results in increased fatigability of inspiratory muscles following successful weaning from MV.
Costs for each arm of the trial will be analysed by components of the intervention pathway (e.g. pre-consultation, work-up, theatre, post-treatment, follow-up, management/coordination, side-effects, etc).; by expenditure category (e.g. capital, staff, consumables, overheads, other); and by incidence (i.e. who bears the costs).
The primary trial outcome will be analysed under an intention-to-treat framework where services are analysed based on the groups to which they were allocated, regardless of the treatment type or exposure received.
The primary trial outcome will be analysed under an intention to treat framework.
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