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To validate both systems, samples from vaccination/challenge trials were tested.
Between 15 and 20 vaccines, as many as are currently in clinical trials, were tested between 1987 and 2000 but were dropped because they were either unsafe or ineffective.
For N270 and RT only the correct-response trials were tested.
To monitor the acute effects of AM281 + AM630 treatment, animals in preliminary trials were tested before and 30 minutes, 1 hour and 2 hours after drug or vehicle injections (n = 6 per group).
Practice trials were tested individually and feedback response accuracy (defined as selecting the correct response key for higher color saturation and orientation, or higher contrast and orientation) was shown at the end of the practice trials.
Typically, 100 trials were tested after muscimol infusion followed by simple pursuit using a single spot (0.5° diameter) and moving it sinusoidally at different frequencies (0.3 1.5 Hz, ±10°).
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Heterogeneity between trials was tested using a χ2 test.
Heterogeneity between trials was tested and interpreted using I 2 percentages.
The product is now in expanded phase 1-2 trials, being tested around the world in various populations.
Statistical heterogeneity across trials was tested by Cochran Q test.
Heterogeneity between trials was tested using the chi-square test, with P <0.10 indicating significant heterogeneity (difference) [ 23].
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