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Dr. Melissa Palmer, who was a practicing liver specialist until last fall, said that the trials were small and patients were usually not followed long enough to see if they were truly cured.
Most trials were small and had some design limitations.
Of note, the differences in adverse event rates derived from the randomized controlled trials were small, introducing an element of uncertainty to the sensitivity analyses.
Previous trials were small, with high risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups.
The sample sizes in some trials were small.
Trials were small and often of limited methodological quality.
Similar(6)
The previous trials were smaller single centre studies.
Most clinical trials are small, and small trials are often associated with larger effect sizes.
In addition, the straight rule can yield counterintuitive results where the number of trials is small.
Sample sizes in published trials are small.
The individual trials are small and therefore underpowered.
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