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Blinded, randomised-controlled trials were retrieved from Scopus and Cochrane Central Register of Controlled Trials databases.
In addition, registered trials were retrieved from trials registries (ClinicalTrials.gov and the International Standard Randomised Controlled Trial Number).
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The remaining 47 trials were retrieved for more detailed evaluation.
From these systematic reviews, data for 1 012 trials were retrieved; 143 duplicate reports and reports of 129 nonrandomised trials were excluded.
From ClinicalTrials.gov, 149 273 records of clinical trials were retrieved.
Six trials were retrieved including 875 patients.
In addition, registered but not yet published trials were retrieved.
All full articles with potentially relevant trials were retrieved.
Clinical trials summaries were retrieved from clinicalstudyresults.org, the former online public registry sponsored by the Pharmaceutical Research and Manufacturers of America (PhRMA).
N rates as applied and yield monitor data for each trial area were retrieved from the Donalds' AgLeader software at the end of the season.
Current Controlled Trials ISRCTN99442407 Findings were retrieved from a cluster-randomised controlled trial with a well-powered sample.
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