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Randomized controlled trials were preferred but also full-text articles of retrospective or prospective studies evaluating the efficacy or the feasibility of mifepristone treatment in meningiomas were included.
Pot trials were preferred to field trials as they afford superior control over extraneous conditions (and especially variability in soil composition) when basic principles, such as those studied here, are under investigation.
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While in principle, equivalence trials are preferred, non-inferiority trials may be considered if appropriately justified, such as for a medicinal product with a wide safety margin.
Randomised clinical trials (RCTs) and, in particular, direct comparison trials are preferred to protect against selection bias in clinical studies through blinding and randomisation [14].
Practical trials are preferred when there is extensive evidence from physiological and epidemiological studies.
superiority trials are preferred over noninferiority trials due to the clinical value of the previous over the lattere; 4).
In principle, randomized controlled trials are preferred, but significant challenges should be recognized in their application to HSCT in ADs (level III).
However, the steering committee of the study does feel that adjuvant treatment unless proven to be inferior of peri-operative chemotherapy in a randomized trial, is preferred.
In the specific case described in this article, a cluster-randomised community-based trial was preferred to a "simple" RCT since the latter would have posed both operational and ethical problems as single households within the same community would have had to be selected to receive the intervention, i.e. the offer to insure [ 14, 31, 36].
Given this serious limitation, in this narrative review we presented the most relevant studies on this topic (Table 1) taking into account the "evidence-pyramid" [ 38]: whenever available, data from controlled clinical trials (randomized/not randomized) were preferred over uncontrolled trials or case series, unless reporting relevant clinical results in terms of efficacy or tolerability.
Lower concentrations were preferred.
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