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Eight trials were placebo-controlled.
Evaluation of pharmacological interventions was most common (40.3%) and 30% of trials were placebo-controlled.
All trials were placebo-controlled, and none involved a direct comparison of IIb/IIIa inhibitors.
All trials were placebo-controlled studies of 5 years of tamoxifen administration.
All the comparative trials were placebo-controlled and powered only for the comparison of topiramate with placebo.
Six trials were placebo-controlled [ 65, 79, 82, 85- 87], and four of those were also double-blinded [ 65, 79, 82, 85].
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All three trials were placebo controlled.
10 11 13 Five trials were placebo controlled and two were comparisons against active treatments.
Three of these trials were placebo controlled [ 12, 18, 22], and two were compared to standard pharmaceutical treatment forms [ 13, 23].
One trial was placebo-controlled and two allocated the control group to observation or usual care.
The trial was placebo-controlled to week 24, dose-blind to week 48 and is open label to week 204.
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