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Industry funded trials were less likely to include cost information.
Industry funded trials were less likely to mention a name in their registered records than partially industry funded trials or non-industry funded trials (OR = 15.9, 95% CI: 9.9 25.5, p<0.001).
Easterbrook et al [26] found that compared with unfunded studies, government funded studies were more likely to yield statistically significant results but government sponsorship was not found to have a statistically significant effect on the likelihood of publication and company sponsored trials were less likely to be published or presented.
They also noted that patients enrolled onto clinical trials were less likely to be uninsured, and more likely to have Medicare (in 2000 Medicare policy was changed to cover the routine costs of trial participation).
This may also partly explain why participants in clinical trials were less likely than those in observational studies to perceive that refusal to participate in the study would affect their regular medical care.
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One of the big problems is that patients who get the vaccines in clinical trials are less likely to benefit from these products because regulatory rules compel companies to test them on the sickest patients.
69 Since small, negative trials are less likely to be published, such missing trials would generally decrease the efficacy estimate.
There is empirical evidence that studies with negative results (null findings for clinical trials) are less likely to be in the published literature (Hopewell et al. 2009).
The more conservative non-inferiority boundaries in the apixaban and edoxaban trials are less likely to be a concern in regards to approval by the FDA.
More overlap trials were presented because these trials are less likely to yield valid reaction times (infants may look away or become stuck on the central fixation), especially in atypical infants.
While clinical trials with fewer human subjects would likely make for more affordable vaccine prices, smaller clinical trials are less likely to expose rare adverse effects or establish efficacy.
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