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A total of two phase II and four phase III trials were incorporated, comprising 3060 enrolled patients.
When considering chemotherapy, targeted therapy or multimodality treatment, only data from phase III trials or randomised phase II trials were incorporated.
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Only a small proportion of relevant trials are incorporated into systematic reviews [ 6].
Lessons learned from this trial were incorporated into a clinical trial in MPSIIIA that employed transient immunosuppression alongside intracranial injections.
Additional details of how the summary results from the FACIT trial were incorporated are provided in the Supplementary Material: Methods Appendix (under "Supplemental data" in the online issue).
When the results of this trial were incorporated into a meta-analysis with the previous randomised controlled trial assessing hospitalisation and bed rest for women with a triplet pregnancy, (total sample size 26 women and 78 infants), there were no statistically significant differences identified between the two groups.
Several currently ongoing and planned adjuvant trials are incorporating gemcitabine (either sequentially or in combination) into anthracycline/taxane regimens.
Safety and efficacy are of primary concern with such cell therapies and some current trials are incorporating the use of serum-free culture conditions for the ex vivo manipulation of HSCs.
All-cause mortality from the trial was incorporated into the QALY estimates in the sensitivity analysis.
The log hazard statistics from a multi-arm trial are incorporated in the analysis using the following likelihood functions.
If no response was made during this time, the trial was incorporated at a random point later during testing.
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