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Estimates of efficacy obtained from clinical trials were adjusted better to reflect effectiveness in the real world by reference to treatment coverage (the proportion of people in need of the treatment who receive it) and adherence (Table 3).
The adverse event rates observed in the randomised controlled trials were adjusted by assuming that halving the dose results in a reduction in adverse events of a quarter.
Similar(57)
The sessions of the second test, 49 56, were identical to positive patterning sessions except that the number of trials was adjusted so that an increased number of test trials could be included.
Our modeling approach suggests that fingolimod therapy results in a higher probability of NEDA than dimethyl fumarate and teriflunomide therapy when phase 3 trial data are indirectly compared and differences between trials are adjusted for.
It was not clear if SDs for the cluster randomised trial were adjusted for clustering, and the precision of these effects (and their weight in the analysis) may be overestimated.
Also a PCA is used, but instead of shifting a window over the data and normalizing by the last w trials, a method similar to [13] is used: a polynomial is fitted to the content of the window and the next trial is adjusted by the value, the polynomial function would estimate.
After the first 9 trials, contrasts were adjusted depending on the response to the previous trial.
Three trials (Ansah 2010 GHA; Skarbinski 2009 KEN; Yeboah-Antwi 2010 ZAM) acknowledged baseline imbalance in the number or quality of the health workers enrolled into the trial, which were adjusted for using different methods.
Yield data from experiments in 2010 were replicated, whereas data from trials in 2009 were adjusted means from an alpha lattice incomplete block design with adjustment for spatial variability in the direction of rows and columns using the autoregressive model fitted in both directions.
To counteract differences in pain assessment and baseline covariates that could eventually occur among the three trials, all analyses were adjusted by stratifying by RCT.
Masked, adjusted oximeters were used in this trial so that some were adjusted to display masked values 2% lower than actual SpO2, and others displayed masked values 2% higher.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com