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During testing, four non-reinforced gap trials were added to the trial types randomly selected for.
Additional 60 prime-target filler trials were added.
To investigate feasibility also non randomized controlled trials were added.
From the third day, the trials ASSwS and nASSwS were weekly added with 300 mL of S. maltophilia LMG 6606 cell suspension (concentration at about 108 CFU mL−1), while the trials ASwR and nASwR were added with the same volume of Ringer's solution.
One additional mixture from the preliminary trials was added.
A recently reported fifth trial was added in the CHERG analysis (the COMPAS trial) [ 22].
Whilst attempting to reach these glycaemic goals, OHAs and/or prandial insulin doses taken at baseline could be continued or modified during the trial, and human regular insulin could be added with meals even if not used at baseline, at the investigator's discretion.
To help combat floor effects associated with recognition, trial scores were added across 5 consecutive trials (rather than 2 trials, as above).
Additional trial centres were added, to improve recruitment, during 2012.
However, as trials with both flashes and beeps had four possible spatial configurations compared with the two possible with flash-only trials, only the LL and RR trials (common to all trial types) were added.
Quasi-experimental static-groups comparisons were added besides the randomized trial, with a more junior group of 4th year students not yet exposed to the EBM intervention (M4 non-EBM) and a more senior group in 6th year that had the EBM course during the previous year (M6 EBM).
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