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"Your low-laid son our godhead will uplift: / His comforts thrive, his trials well are spent".
That is small payment for a drug with presumably a huge potential market, probably reflecting that Alnylam is still in the first of three phases of clinical trials, well behind some far bigger competitors.
In randomised trials, well over 30% of the patients with stage II or III rectal cancer developed distant dissemination.
There are few randomized controlled trials; well designed studies should include larger numbers to generate a higher quality of evidence.
Table 3, highlights countries with what may be strong traditions of undertaking and disseminating trials, well beyond that predicted by GDP.
The delayed randomisation element of this trial gave doctors opportunities to discuss the scientific imperatives and the science of trials well before they discussed randomisation.
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In the absence of randomized clinical trials, well-designed and critically analyzed observational studies can provide similarly valuable evidence.
Although the effectiveness of therapeutic apheresis may be established from uncontrolled trials, well-designed, randomized controlled trials provide the best evidence for a clinical benefit because this type of trial design minimizes bias.
As the patients' records are not currently stored in a database in a format which is directly accessible, an object-oriented model is proposed, which includes prognosis factors currently tested in clinical trials, well-established ones, and a description of the illness episodes.
For research databases and randomised trials, well-characterised and relevant outcome measures are very important.
Because strategies targeting this latent reservoir are now being tested in clinical trials, well-validated high-throughput assays that quantify this reservoir are urgently needed to evaluate the effectiveness of these interventions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com