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Although we agree with the power of randomized clinical trials, we argue in this paper that random assignment raises other, unanticipated threats to internal validity as a result of failing to consider treatment preference in research participant behavior.
To prevent or anticipate difficulties in N-of-1 trials, we argue that that it is important to individualise the outcome measures, and to carefully consider the objective, type of randomisation and the analysis.
Although this result need to be confirmed by further clinical trials, we argue that, for patients who received neoadjuvant chemoradiotherapy, adding oxaliplatin to fluoropyrimidines in the postoperative chemotherapy require serious consideration at present.
Similar(57)
Since the proportion of patients with poor PS did not differ in this and in our previous trial, we may argue that the pragmatic adaptation of treatment intensity represents a good way to improve the tolerability of cytotoxic drugs in elderly people.
We argue that trials targeting healthy humans are often fundamentally flawed owing to inappropriate use of paradigms only applicable to populations with overt clinical disease and the consequent misleading (typically negative) results can severely retard advancement of drug development.
We argue that for many trials conducted in palliative care, the feasibility of conducting the proposed trial should be formally explored before implementation.
Serious talk about war crimes trials, they argue, can prolong wars and thwart postwar efforts to build peace.
Increased risks of ischaemic cardiovascular events in randomised trials also argue against confounding as an explanation.
But critics of the trials argue that the new science behind the drugs has eclipsed the old rules — and ethics — of testing them.
These progresses and results of ongoing well designed clinical trials argue in favour of further development of PDT with systemic delivery of the drug as a viable therapeutic modality in the near future.
These field trials argue in favour of the strategy of mixing repellent and organophosphate on bed nets to better control resistant malaria vectors.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com