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The presence of heterogeneity across trials was evaluated using a chi-square test for homogeneity [16] and random-effects and fixed-effects were used accordingly to determine pooled estimates of the growth rate difference across studies [17].
Homogeneity of the odds ratios across trials was evaluated using a Breslow-Day χ2 test.
Heterogeneity of treatment effects between trials was evaluated using the chi-square test and I-squared (I) statistic [ 18].
The quality of the trials was evaluated using Jadad quality scores [ 13], and included secure methods for randomization, allocation concealment, patient and observer blinding, and loss to follow-up.
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The controlled clinical trials were evaluated using the Newcastle Ottawa Scale.
Heterogeneity across trials is evaluated using the chi-square test as calculated in M etaV iew.
Randomized studies are needed to compare outcome of weaning in patients whose clinical tolerance to spontaneous breathing trials is evaluated using either strict criteria or less strict criteria.
Change in admission frequency over the 24-month trial was evaluated using repeated-measures Poisson regression.
The methodological quality of each trial was evaluated using the five-point scale (0 = worst and 5 = best) as described by Jadad and colleagues [ 19].
The methodological quality of each trial was evaluated using the Jadad scale [ 21] and the risk of bias assessment tool in the Cochrane Handbook for Systematic Reviews of Interventions [ 22].
Patients who passed a spontaneous breathing trial were evaluated using the modified Airway Care Score ACSS) to assess their ability to control their respiratory secretions (Table 1) [ 11].
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