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In parallel with the trials, validation studies of the new instrument were conducted in the UK, US, France, Germany and the Netherlands.
The more recent clinical introduction of CAD to assist radiologists in the detection of actionable lung nodules will likely be followed by the development, clinical trials validation, regulatory approval and commercialization of a variety of CAD applications in diagnostic imaging.
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However, both the safety and efficacy of using anti-FcμR CAR T cells to treat CLL require further clinical trial validation.
Long-term experiments are scheduled for the new prototype that is currently under development and being enhanced based on the outcome of the field trial validation.
Novel interventions, such as vaccines, microbicides, or chemoprophylaxis, will all require clinical trial validation.
We then validated the model by demonstrating that it closely approximated several key outcomes for a separate group of patients followed less intensively in the same trial (validation).
TØ contributed to the design, implementation of the trial, validation and management of the main database, analysis and interpretation and drafting the paper.
The prediction model performed better in the clinical trial validation cohort (area under the receiver operating curve 0.81, 95% confidence interval 0.77 to 0.84) than in the population-based validation cohort (0.71, 95% confidence interval 0.65 to 0.76).
In the clinical trial validation cohort, the model predicted death or ventilator dependence better than day 1 SAPS II and Acute Physiology and Chronic Health Evaluation (APACHE) II scores (P < 0.01; Figure 2).
The primary outcome (death and/or ventilator dependence for longer than 14 days) occurred in 68% of patients in the international derivation cohort (VENTILA), in 60% of patients in the clinical trial validation cohort (ARDS-net), and in 59% of patients in the population-based validation cohort (KCLIP; Figure 1).
In each validation trial, validators saw one of the 504 validation stimuli.
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