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Several of the major toxicities of concern for cyclophosphamide, including ovarian failure and bladder cancer, usually manifest after either higher cumulative doses of cyclophosphamide or longer follow-up times than present in the trials under discussion.
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There are multiple serotypes of AAV [ 23], but serotype 2 (AAV2) has been used in nearly all human trials, including the arthritis trial under discussion.
The initial clinical trial of Avastin that was under discussion was conducted by an academic group without some of the procedures in place that the F.D.A. would have liked.
Glucose control strategies and recommendations on HbA1c targets are currently under discussion since findings from recently published trials, such as ACCORD, ADVANCE and VADT have not demonstrated a significant reduction in cardiovascular disease with intensive glycemic control [ 22, 23].
Until results of the RTOG 0534 trial have matured, the role of adjuvant WPRT will remain under discussion.
One of the therapies under discussion will be homeopathy, and the evidence from clinical trials suggests that homeopathic pills are nothing more than placebos.
These therapies are under discussion for treatment of ovarian cancer and numerous clinical trials are already in progress [ 16], however, not all patients respond equally to this treatment.
Because the effectiveness of SLIT is still under discussion (mainly due to inconclusive quality/methodology of the published trials), the present long-term study is expected to provide useful information about SLIT with house dust mite allergen in primary care.
Such a study is under discussion among US and European cooperative groups and two randomized trials, one sponsored by the Turkish Federation of the National Societies for Breast Diseases and the other by Tata Memorial Hospital, India, are currently recruiting.
The timing of starting TPN in the ICU group is under discussion and has recently been studied in the EPaNIC trial; late initiation might be preferable [ 42].
Replacements are under discussion.
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