Every trial under consideration successfully established the contraceptive effectiveness of levonorgestrel for preventing unintended pregnancy.
With an array of new agents and predictive biomarkers to investigate, the time for further randomised trials to compare neoadjuvant endocrine treatment with conventional chemotherapy in a broad spectrum of patients with ER+ breast cancer has probably passed – particularly if the trial under consideration is not prospectively testing a predictive biomarker for endocrine responsiveness.
The Osteoporosis Choice II trial, a patient level randomized trial, [manuscript under consideration at a peer-reviewed journal] took place in a primary care setting between May 2009 and April 2010 with follow up of 6 months.
Three phase III trials of the rhGAD65-alum vaccine are underway in the U.S. and Europe (Table 2), and a secondary prevention trial is under consideration.
Another clinical trial currently under consideration (NCT01640847 on clinicaltrials.gov) involves the use of TSLs for pain palliation in bone metastases.
An early phase clinical trial is under consideration for low-dose warfarin based on the combination of findings we report here, other preclinical studies (Brown, 1973; McCulloch and George, 1987; Schulman and Lindmarker, 2000; Kirane et al., 2015) and anecdotal observations in patients (Brown, 1973; McCulloch and George, 1987; Schulman and Lindmarker, 2000; Kirane et al., 2015).
Different adjuvant therapies, including immunomodulation, are being tested in clinical trials or are under consideration in hopes of addressing these remaining challenges [ 2].
Holder also reiterated that the location of the alleged 9/11 co-conspirators' trial is still under consideration by the Department of Justice.
The review was limited by the lack of trials assessing the intervention under consideration: docetaxel plus prednisone.
The precision of this estimation is limited mainly due to the lack of long-term head-to-head trials between the treatments under consideration.
