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Surveillance analysis should be guided by a priori evidence (such as nonstatistically significant adverse events) from phase III clinical trials to limit the potential for false-positive results.
This could be a black circle (50% probability), square (25% probability) or triangle (25% probability), which substituted the fixation cross provided between trials to limit confounding eye movements (Fig. 1).
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In addition, six "dummy trials" were included, where the height of the step was randomly adjusted by −10 mm or +5 mm every third trial to limit the effectiveness of using somatosensory feedback from previous trials to estimate the height of the step.
Participants were asked if they wished to rest between each trial to limit fatigue and stress effects.
Six trials of each test posture were conducted with 30 seconds rest between each trial to limit the effects of fatigue.
As discussed above, the generally low methodological quality of trials continues to limit the ability to evaluate the evidence base.
After Judge Hilton's ruling, Gator asked the court to expedite the trial, presumably to limit lost revenues.
The couple who abandoned their severely disabled son at a Delaware hospital last December have agreed to a year's probation instead of a trial, and to limit contact with their son to supervised visits.
Baseline comparison of intervention and control sites for the main trial aimed to limit this bias to some extent.
These criteria were designed by the trial investigators to limit the sample to moderate to severe dementia patients having recognizable behavioral disturbances.
Despite these robust findings, there is a need in clinical trial research to limit the number of items to as few as possible and to minimize patient responder burden.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com