Phase 2 involves a randomised controlled trial to implement and evaluate the programme.
We performed a rigorously designed cluster-randomized trial to implement IC interventions in small rural hospitals in the western United States.
For any trial to implement a stopping rule successfully there must also be prompt feedback and processing of response and survival data ready for up-to-date analysis.
Anti-Id mAbs mimicking the human high molecular weight melanoma-associated antigen have been tested in a clinical trial to implement active specific immunotherapy (Mittelman et al, 1990).
One GP participated in a trial to implement the screening protocol for cardio-metabolic prevention, targeting all patients >55 years old [ 16, 24].
The IPaC study is the first randomized controlled single centre phase III trial to implement an early palliative care approach in standard oncological care in the hospital setting in Belgium for patients with advanced cancer.
Since July 2012, an intervention trial to implement a simplified neonatal resuscitation protocol provided by Helping Babies Breathe (HBB) has been ongoing at Paropakar Maternity and Women's Hospital in Kathmandu, Nepal [ 24], which is a central referral hospital of the country and also a teaching hospital for medical and nursing students on all levels.
One interpretation, offered by Frieden 2007, is that these trials failed to implement direct observation effectively.
Other previous randomised controlled trials designed to implement LBP guidelines (and change the behaviour of clinicians) have used different intervention including educational outreach, multi-faceted intervention with workshops and printed educational material, dissemination, and audit and feedback [ 24, 25].
The overall aim of the clinical trial is to implement and evaluate a clinician‒focused intervention designed to facilitate health behavior change discussion.
