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But for the companies, the competition could mean smaller markets for each drug and costlier clinical trials to differentiate a product from its competitors.
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The other issue is the evaluation of assay sensitivity, which refers to the ability of a trial to differentiate an effective treatment from a less effective or ineffective treatment [ 5].
Thus, the fourth trial serves as a probe trial to differentiate between participants using a spatial strategy and those using a response strategy; the rationale for the probe being that if participants were using a spatial strategy, this change in the environment should result in an increase in errors, whereas the use of a response strategy would not (Iaria et al., 2003).
Since this could increase right ventricular (RV) afterload, we investigated the effect of this method on RV outflow impedance during inspiration and expiration using transoesophageal echo-Doppler in a trial to differentiate the RV consequence of increasing lung volume from those secondary to increasing airway pressure during mechanical ventilation.
The proactive index is a standardized score based on the relative performance on AY versus BX trials, assuming that these trial types are complementary, 2 while normalizing across total error rates on both trials (in order to differentiate selective from general performance patterns).
Since results of trials that aim to implement comprehensive care programs for frail, older people have been conflicting, assessing implementation fidelity alongside these trials is essential to differentiate between flaws inherent to the program and implementation issues.
The trial was designed to differentiate between the two drugs in the shortest possible time by enrolling patients at increased risk of early recurrence of breast cancer, so that the number of events required to initiate analysis will be obtained more quickly.
Randomised controlled trials should also help to differentiate between the effectiveness of types of psychosocial interventions.
On the some occasions, a therapeutic trial is also essential to differentiate to various TACs.
Furthermore, principal components analysis was able to differentiate the trials with respect to agronomic and quality trait of radish.
16 32 33 We evaluated the risk of bias tool and showed its ability to differentiate between trials that may have overestimated treatment effects.
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