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The TLR agonist rEA has been shown in mouse and human clinical trials to correlate with functional improvements in the quality of the innate and/or adaptive immune responses elicited [11], [13], [14].
Based on these results, it will be important to design clinical trials to correlate clinical responses to HER2-targeted therapy by HER2-positive CTCs in metastatic cancer.
As this assay produces results in a high percentage of tests and is rapid and simple it appears suitable for prospective clinical trials to correlate the in vitro results with in vivo response.
As all the clinical trials from which data were extracted did not include objective response as an end point, we were only able to use unconfirmed response data recorded by study investigators in two of the three trials to correlate CA19-9 responses to radiographic responses.
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However, future studies are necessary to establish the ability of MRI/3D-MRSI to accurately assess patients with premalignant or very early malignant changes, to validate metabolic markers as intermediate endpoints in chemoprevention trials, and to correlate metabolic endpoints with other promising intermediate biomarkers.
Treatment doses, as well as dose increases were taken from clinical trials in order to correlate doses with clinical efficacy.
Further human trials are needed to correlate the level of ex vivo anti-adhesion activity with prevention of clinical UTI.
These two configurations were balanced across both test and training trials to avoid correlating them with cube rotation.
This trial has been powered to correlate the clinical effects of DAB/IL2 with the depletion of peripheral blood Treg cells.
CML levels in skin collagen sampled at the end of the Diabetes Control and Complications Trial (DCCT) were shown to correlate with later development of DN (35), but our approach does not require such an invasive procedure to obtain tissue.
This long-term priming effect did not decay throughout a Neutral block of 200 trials, and did not appear to correlate with the extent to which participants subjectively experienced the bias.
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CEO of Professional Science Editing for Scientists @ prosciediting.com