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In clinical trials, therapy with exenatide QW as monotherapy or in combination with other antidiabetic treatments was associated with reductions in glycated hemoglobin (−1.3% to −1.9%), fasting plasma glucose (−32 to −41 mg/dL), and body weight (−2.0 to −3.7 kg).
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63 In the SUMMIT and CREST trials, therapy-associated thrombocytopenia occurred in 42% of study participants, and was the most frequently reported grade 3 adverse event.
For certain patient populations, we are starting to see, either in practice or clinical trials, therapies with the potential for long-term survival and even cure.
Contraindication or previous intolerance to any trial therapy.
A platinum therapy free interval of ⩾6 months was required prior to initiation of trial therapy.
The mean duration of trial therapy was 26.07 weeks (range 0.14 83.43 weeks).
A positive pinnal pedal reflex has been associated with Sarcoptes and justifies trial therapy [ 21].
The results of the trial therapy after 1 week are shown in Figure 3.
The safety analysis was performed for the safety population (patients who initiated trial therapy).
Serum creatinine and cystatin C were measured at trial end and 6 8 weeks after discontinuation of trial therapy.
In November of 2006, the patient commenced VMCL vaccine trial therapy, and he has remained disease-free since.
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