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"From everything we're seeing in the clinical trials, the trend is that the statins are being shown to be helpful in many more situations," said Dr. Dana McGlothlin, a cardiologist at the University of California, San Francisco Medical Center.
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In a retrospective analysis of the moderately severe to severely ill patient subset from this trial the trend toward improved global response persisted [ 39].
This trial follows the trend in results highlighted in the previously published literature with a moderate improvement in symptom severity score which is difficult to interpret in regard to clear clinical benefit.
When we further restricted this analysis to placebo-controlled trials, the test for trend was not statistically significant (test for trend P=0.134).
In the AMICI trial, the observed trend for a larger prevalence of diabetes in the patients with LV remodeling versus those with reverse remodeling is in accordance with the known abnormalities of coronary flow reserve, endothelial function, ischemic preconditioning, and prothrombotic state in these patients.
The methodological quality of the included studies was assessed independently by two reviewers using "Consort 2010" checklist for the randomized controlled trials or "TREND" for the quasi-experimental studies.
Additional follow-up from the substantive phase III trials is needed to confirm the trend for improvement in PC-specific and OS.
The overall results are generally the same with two major exceptions: 1) the significance of the modulation during the Go decision trials is trending in the direction predicted by the drift-rate modulation model, but is not statistically significant.
While the trial numbers are quite low, the trend in the data supports a hypothesis that just participating in the process may lead to increased learning.
7 A χ test for heterogeneity among studies included in the meta-analysis revealed an I of 97% with a p value of <0.00001, indicating significant heterogeneity among these studies (although the heterogeneity was quantitative rather than qualitative as all the trials demonstrated the same trend).
Though national statistics are not readily available, the trend toward lower trial rates is evident in a number of places.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com