Sentence examples for trials the problem of from inspiring English sources

The only other difficulty the organizers encountered, besides the unexpectedly high incidence of hazardous toxicity with busulphan in the early stages of the study, was one that is very common to treatment trials: the problem of ensuring that patients took the right number of tablets, not more and not fewer than they had been prescribed.

Most observational trials had the problem of confounding or small sample size.

Moreover, the use of cut-offs for the total scores categorizing trials reverts to the problem of looking at trial design as purely explanatory or pragmatic [ 8, 16].

However, there are few candidates in late-stage clinical trials suitable for the problem of Gram-negative pathogens.

In 2003, for example, she helped devise a randomized trial that addressed the problem of absentee teachers in schools run by an Indian nonprofit group.

Since acquired knowledge of ACEP Clinical Policy on Hypertension did not translate into changes in physician practice in Lehrmann's trial, we approached the problem of adopting evidence-based guidelines in clinical practice at the next level in the hierarchy of interventions, namely, transfer of learning to the workplace via evaluation of behavior.

In line with earlier literature these two articles demonstrate that serious attempts have been made in the past decades to define the different states between dead and live (marine and oral) microorganisms, and that "viability staining" or "vital staining techniques" have been and are still used as a trial to overcome the problem of distinguishing between live and dead microorganisms in biofilms.

The problems with external validity of trials, and in particular, the problem of highly selected trial populations have been highlighted recently [ 27].

Key targets for drug development, current clinical trials, and the problems of developing drugs that do not have direct cytotoxic effects are reviewed.

The high rates of failure in oncology drug clinical trials highlight the problems of using pre-clinical data to predict the clinical effects of drugs.

Whilst measuring the central tendency of the group across trials reduces the problems of interdependency of the data and type-two clustering errors [34], the cost is a substantial reduction in statistical power.