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In both trials, the implementation of mild hypothermia achieved a survival rate without major sequel in approximately 40-50% of a highly "selected" population (OHCA with an initial rhythm of ventricular fibrillation in front of a bystander).
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However, for a particular trial, the implementation of these methods requires extensive computer programming.
Given the constraints imposed by the trial, the implementation of SASA! was somewhat truncated.
This paper describes the design of the trial, the implementation of the study protocol in a child and adolescent psychiatric outpatient unit, and the data analysis strategies.
However, to ensure that all the wards involved can benefit from the improvement brought by the Program, unless it proves to be not effective, at the conclusion of the trial the implementation of the LCP-I Program will be proposed also to the control wards.
This is the first large scale randomised controlled trial to test the implementation of cancer risk tools based on the Hamilton CAPER studies.
This study is one of the few cluster randomized trials concerning the implementation of clinical practice guidelines in Spanish primary care.
The evidence from controlled trials and the implementation of stage-and disease activity-adapted regimens have particularly contributed to the improved outcome.
A review of randomized controlled trials with the implementation of screening for depression symptoms in routine care revealed little or no impact on the recognition, management, or outcome of depression in primary care or the general hospital [ 40].
40 41 Identifying key points of intervention and outcomes of importance to patients are essential to the development of well-designed pragmatic trials and the implementation of efficient, patient-focused clinical services.
In future research work screening studies should be developed to compare screened children with children who did not undergo screening (ideally in randomised controlled trials without the implementation of a current screening programme in the control group).
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