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We hope that the atypical experiences of a small group of self-proclaimed "guinea pigs" will not dissuade people from taking part in the essential clinical trials that underlie medical progress today.
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article summarizes the proceedings of this meeting and addresses: (1) adverse trends in the United States and multinational clinical trials, (2) the key issues that underlie these adverse trends, and (3) potential solutions to these problems.
Such an interaction might warrant a change in the assumptions that underlie current trial designs.
The factual circumstances that underlie a speedy trial claim, however "extraordinary," cannot establish its independent appealability prior to trial.
Our conclusion, however, is reinforced by the important policy considerations that underlie both the Speedy Trial Clause and 28 U.S.C. 1291.
The development of trials that begin to match treatment arms to underlying molecular characteristics (e.g., FOCUS3) should be widely supported and further developed.
In this randomized controlled trial we aim to further investigate the neural mechanisms that underlie fatigue in CFS and their change by CBT.
19 20 Randomised comparisons within trials are preserved and the main assumption that there are no systematic differences between the trials that could bias the indirect measurements is similar to those underlying any standard meta-analysis.
There are few randomized, controlled clinical trials that have directly compared IV iron products in patients with IDA of any underlying cause 21– 21.
Randomized controlled trials of IBMT indicate improvements in specific EF components, and uniquely highlight the role two brain-based mechanisms that underlie IBMT-related improvements.
Treating the underlying cause may improve aspirin sensitivity but current data are contradictory with no large clinical trials that have addressed this.
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