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She thereafter resumed her duties as escort for Hohenzollern, and during this period she conducted further sea trials that confirmed her cruising radius, which was the highest of all German ships at the time.
It has been tested in two clinical trials that confirmed its safety in humans [28,47].
The phase III trials that confirmed the benefit of sunitinib, bevacizumab + IFN, and pazaponib each enrolled a small proportion of patients with poor prognostic features.
These compounds have been the subject of clinical trials that confirmed their clinical efficacy without the cardiovascular side effects commonly associated with triptans [4,5].
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However, proof-of-concept clinical trials that confirm the value of matching investigational targeted treatments to rare molecular alterations in breast cancer and other malignancies are beginning to emerge [ 12].
Prospective data from phase III trials that confirm a survival advantage for such a treatment regimen are still lacking; however, phase II data have shown the feasibility and tolerance of these concepts (Ko et al, 2007; Moureau-Zabotto et al, 2008).
Unfortunately few centres have reported long-term outcomes to validate this approach and there are no reported controlled trials that confirm the efficacy of these treatments (Onik et al, 2008; Challacombe et al, 2009; Lindner et al, 2009; Warmuth et al, 2010).
However, there is currently no real randomized controlled trial that confirms these data and results concerning mortality remain uncertain [82, 85].
Proof of concept was demonstrated in animal models resulting in clinical trials that have confirmed the feasibility and short-term efficacy of intramuscular injection of angiogenetic tissue growth factors or bone marrow stem cells.
Similar data have been seen in clinical trials that have confirmed the efficacy of switching to abatacept from an anti-TNFα agent, thus suggesting that using a drug with a different mechanism of action may help.
The first was a 6-month, open-label, randomised clinical trial that confirmed that asthma control can be well maintained in children aged 5 11 years when switching from a conventional CFC-BDP metered dose inhaler (MDI) inhaled via a spacer to ultrafine HFA-BDP (administered via an Autohaler®) at doses as low as 100 200 μg/day [ 62].
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CEO of Professional Science Editing for Scientists @ prosciediting.com