Sentence examples for trials substantial from inspiring English sources

Although the efficacy of medications for attention-deficit/hyperactivity disorder (ADHD) is well demonstrated in clinical trials, substantial numbers of patients fail to remain on therapy, and there is tremendous variability in tolerability and treatment acceptance.

In the ten years since the surprising early termination of those two WHI clinical trials, substantial discussion, critique, reanalysis, and opinion has been offered to reconcile the differences between the WHI clinical trial results and a diverse set of a priori and a posteriori expectations.

However although bat activity was significantly reduced during experimental trials substantial numbers of bats continued to forage within the beam.

After application of different eye drops and desiccation trials, substantial differences in cell viability could be noticed between particular preparations.

In a pooled analysis of four statin random controlled trials, substantial reduction of LDL-C accompanied by an approximate increase of 7.5% in HDL-C with statin therapy, was associated with coronary atherosclerotic regression.

In Liraglutide Effect and Action in Diabetes (LEAD) 1 6 trials, substantial and sustained improvement in HbA1c, fasting plasma glucose and postprandial glucose have been observed with liraglutide treatment [ 10- 15].

Within the group of trials reporting substantial crossover on progression heterogeneity between groups is not substantially greater than that within the groups (F1,2=2.53, P=0.25) for overall survival (Table 2).

These companies generally do not move forward and get a product into clinical trials without substantial financing.

Because the clinical, regulatory, and economic impact of active control noninferiority trials is substantial, robust criteria should be used routinely in their design, analysis, and interpretation to reach their intended objectives and to keep them from becoming wasted efforts.

During the radiolabeling trials a substantial amount of the total initial radioactivity in the media was not recovered at the end of the hatching or enrichment period (38% and 29%, respectively).

As will be demonstrated, the level of evidence required to formally and fully validate a new imaging marker as an appropriate end-point for phase II trials is substantial.