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Such issues are very relevant in the context of population-based practice, i.e. involving 'non-study' patients, where, differently from controlled trials, selection criteria and therapy optimization do not usually apply (Thieblemont & Coiffier, 2007).
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Only 493 (51%) non-trial cases passed all of the prospective trial selection criteria for entry.
As a consequence of the trial selection criteria, 92% had splenomegaly.
In both GXR monotherapy studies meeting the initial trial selection criteria [ 12, 13], the target dose range of GXR 0.09 0.12 mg/kg/day was used.
The presence of type 1 (oxygenation) failure and cardiovascular dysfunction are risk factors to consider when future trial selection criteria are designed.
The study sample consisted of all women resident in the counties who became pregnant between August 2002 and January 2006 and who fulfilled trial selection criteria (see below).
The second coder was given a one-page written explanation of the trial selection criteria along with one example file (different from the coded data set).
But briefly the study sample in the trial consisted of all women resident in the two counties who became pregnant during the study period and who fulfilled trial selection criteria.
In sequence, questions asked participants to (1) provide demographic information anonymously (2) rate the importance of each of the hypothesised trial site selection criteria for Europe as a whole, (3) provide perception of the trial environment in 12 European countries and (4) rank areas of potential improvement.
For this analysis, three additional ATX trials met the selection criteria in addition to the three trials included in the base case ('six-trial' analysis).
Twenty-six unique clinical trials met all selection criteria and were included in the review.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com