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Only two small randomised controlled trials satisfied the inclusion criteria.
33 trials satisfied three or more out of five methodological criteria (Jadad scale).
Twelve trials satisfied our inclusion criteria; eight were high quality (Jadad score >2) and four were low quality (≤ 2).
A total of 10 trials satisfied the criteria of a direct head-to-head comparison of two (or more) antidiabetic agents with preintervention-specified endpoints.
28 29 As shown in figure 4, both trials satisfied this primary end point with a better result for BLISS-52.
The highest scoring trials satisfied 36 of 42 items while the lowest scoring trial satisfied only 18 items (median 27, IQR 23 31).
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In practice, none of the trials satisfy both of these criteria [ 4].
The full-text versions of potentially relevant citations were then independently assessed to determine whether the trial satisfied the inclusion and exclusion criteria.
Each item on the scale that the trial satisfied (except for item 1, which assesses external validity and is not included in the total score) contributed one point to the total PEDro score, with 0 representing the lowest score and 10 the highest [4].
If a subject made a mistake, the subject could repeat the test trial until satisfied with his or her test trial.
25 We identified 19 potentially eligible references.w1-w19 We excluded eight references (fig 1).w2-w9 The 11 remaining references provided data on six trials that satisfied the inclusion criteria; six trials provided mortality data, three had relevant data on morbidity, and six provided data on adverse effects.
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