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Randomized controlled trials require a lot of resources and are not designed to answer all research questions.
40 Such trials require a prespecified factorial analysis plan with assessments for treatment interactions.
Early clinical trials require a robust and timely quantitative marker of disease response.
High-quality trials require a broad level of participation to achieve the sample sizes required for adequate power.
This precluded a further meta-analysis, but suggested that Chinese trials require a more stringent study design.
Such trials require a multicenter, maybe even a multinational, approach and concerted action from specialists, patients, and funding agencies.
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Adjuvant registration trials require an enormous financial and patient investment to detect small differences in long-term outcome.
Often clinical multicenter trials require an extensive amount of data to be registered and collected from each patient and participating site.
In fact, more than 50% of clinical trials require an extension because of recruitment issues and more than one-third do not achieve their original recruitment target [ 33], even if financial compensation is given.
The Military Commissions Act of 2006, which set up rules for terrorism trials, requires a significant overhaul, and Congress should hold hearings on how the incoming president plans to use the vast surveillance powers given him by the FISA Amendments Act of 2008.
Evaluation of the efficacy of a preventive HCV vaccine, such as those currently in Phase I/II trials, requires a cohort with a high-risk exposure to HCV.
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