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Defining an adequate endpoint for renal denervation trials represents a major challenge.
The definition of the role of these new drugs alone or in combination with established chemotherapy regimens in adequately designed prospective trials represents one of the major challenges in clinical lymphoma research.
A substantial and variable placebo response can cause unreliable findings in clinical trials designed to demonstrate the efficacy of antidepressants, and the high rate of failed trials represents a major obstacle in the development of new drugs for major depressive disorder (MDD).
However, defining interventions in randomised controlled acupuncture trials represents a challenging task.
The vexing challenge of recruitment to trials represents a substantial impediment to the development of robust, generalisable evidence across healthcare fields.
The strategy with which participants treat absent trials represents a entirely different issue (see [ 5]; for a rare example of modelling absent trials).
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Controlled clinical trials represent the design highlight in biomedical research.
Clinical trials represent new steps in the progress of knowledge.
The trials represented a formal acknowledgement of how pervasive the mafia was in Sicily.
Results: Sixteen trials representing 17 relevant comparisons were included in this systematic review.
Clinical trials represent an important opportunity for the collection of health-utility data.
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CEO of Professional Science Editing for Scientists @ prosciediting.com