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Despite this promise, emerging data from preclinical trials reinforce the need for additional insight into virus host biology in order to facilitate the development of a successful vaccine.
The meta-analyses including data from other trials reinforce this conclusion.
Data from two similar phase III multi-center trials reinforce the findings of the initial dose-ranging study (Johanson et al 2005a; Johanson et al 2008).
While the results from these trials reinforce the penis and its foreskin as a biomedical fact, the cultural interpretation and implications of these results remain significant for HIV prevention.
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Security forces flooded the streets; comprehensive measures to stifle, punish and undercut dissent, from censorship to show trials, reinforced physical repression.
Trials reinforced with 50% sucrose solution followed the same schedule as trials reinforced with electric shock (5 sec odorant and 2 sec sucrose to the antenna and then to the proboscis, starting 3 sec after the odorant onset).
8 16 19 22 23 A recent Cochrane review on oxygen treatment and acute exacerbations of chronic obstructive pulmonary disease in the prehospital setting identified two ongoing trials, reinforcing the medical community's recognition of the need for evidence in this area.
In recent years, a number of researchers have been working on developing adequate methodologies to conduct cluster-randomised trials, reinforcing trust in how such trials can produce reliable evidence in situations when group randomization is to be preferred to individual one [ 14, 30, 31, 33, 34, 37, 57].
This negative trial reinforces the importance of correlating biologic and clinical responses in early clinical trials of targeted therapies.
Fourth, the frequently evidenced failure of the physical activity groups to meet the primary endpoint in trials reinforces views against physical activity.
Thus, the positive inference we attributed to four trials in this category cannot be regarded as admissible evidence; the spuriously large treatment effect evidenced in two of the trials reinforces those serious concerns.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com