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Nevertheless, noticeable protection against the disease – which kills around 500,000 children under five every year – was achieved in recent trials, raising hopes that one of the planet's greatest health scourges could soon be tackled.
Adoptive T-cell transfer showed promising efficacy in recent trials raising interest in T cells with redirected specificity against tumors.
Frequently, encouraging signals of potential efficacy for novel agents in early phase clinical trials have been followed by disappointing failures in larger phase III trials, raising the valid question of how drug development can be optimized for patients with pancreatic adenocarcinoma and biliary tract malignancies.
AIDSVAX, VaxGen's gp120-based AIDS vaccine, failed in clinical trials, raising questions about the strategy of using viral Env protein to induce neutralizing antibody responses.
Two companies in our sample acquired or licensed drugs initially developed by smaller companies, and another used a partner company for some trials, raising questions about whose responsibility it was to ensure trials complied with FDAAA.
Dozens of compounds targeting different viral proteins are currently in different stages of clinical trials, raising the expectation that several IFN-free regimens might be available in the coming years.
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This plan is another candidate for elimination, or perhaps it should be limited to encompass only very widely prescribed drugs whose clinical trials raised a safety signal(s).
But the committee, set up by the National Institutes of Health to help oversee gene therapy clinical trials, raised questions about the process used to enroll the woman in the study.
Hasty trials raise fears of possible miscarriages of justice.
Rushing them into widespread use without large-scale trials raises hopes and concerns.
In pediatric oncology, the conduct of those trials raises specific challenges, as the disease is rare with limited therapeutic options.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com