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Dynamic contrast-enhanced magnetic resonance imaging in prostate cancer clinical trials: potential roles and possible pitfalls.
We will also discuss how the complex regulation of the PI3K/Akt/mTOR pathway poses practical issues concerning the design of clinical trials, potential toxicities and criteria for patient selection.
Using scientific knowledge derived from the literature and process knowledge gathered during development studies and manufacturing to support clinical trials, potential critical and key process parameters with a possible impact on product quality and process performance, respectively, were determined during a risk assessment exercise.
That has made it difficult to design human trials; potential subjects would have to forego immunosuppressive drugs that are standard practice for transplant patients.
If significant heterogeneity existed between trials, potential sources of heterogeneity were considered, and, where appropriate, a random effects model was used.
In both trials, potential subjects could be excluded from participation on the basis of abnormal laboratory findings or medical conditions judged by the investigators to be clinically significant (including chronic pancreatitis).
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The key to achieving this goal is to perform clinical trials to test potential therapies.
WASHINGTON — In the five days it took lawyers to select the jury for Roger Clemens's federal perjury trial, potential jurors were confronted with more than 100 questions.
The exact or self-consistent potential ϕ0(r) is expressed in terms of the trial potential ϕ(r) and a correction potential δϕ(r) φ o r = φ r + δφ r. (9).
Following referral to the MONARCA trial, potential participants were screened and if they met the criteria for participating in the trial, they were included.
Following completion of the main study follow up questionnaires 12 months after entering the trial, potential participants were invited to discuss their experiences of treatment over the past year.
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