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Although there is a lack of strong evidence-based information on these procedures because of the difficulty in designing statistically powerful trials on this topic, physicians must be aware of all available devices to be able to choose the best haemostatic tool for the most effective procedure.
Several major trials on this topic have begun recently, Verhoef said, and the results are expected within the next 2 years.
Therefore, after an original and detailed analysis of all experimental and clinical studies, we herein provide new ideas and concepts that could participate to improve knowledge on oxygen toxicity and help in developing further prospective controlled randomized trials on this topic.
No randomized clinical trials on this topic were found.
Recent trials on this topic are summarized in Table 2.
Concurrently randomized controlled trials on this topic are rare [ 26- 28].
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The one completed clinical trial on this topic 24 did not find a significant improvement in HRQoL.
Results from the Medical Therapy of Prostatic Symptoms (MTOPS) trial, the largest and longest clinical trial on this topic to date, revisited the role of combination therapy in the treatment of BPH.
Because of the ethic limitations, it is hard to perform a randomized controlled trial on this topic.
The last randomised controlled trial on this topic was conducted by Stremler et al. in 2005 [ 19].
Confirming our hypothesis, Nephrologists agreed (72.2%) that clinical equipoise exists among their community and that a randomized control trial on this topic is needed.
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