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We found one study that addressed the outcomes used in clinical trials of regular therapies for childhood asthma, in which the authors ascertained, by questionnaire, the opinions of 14 specialists and researchers about outcomes relating to disease activity, functional status, and quality of life [10].
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One study was a parallel group trial of regular therapy for seven days.
During a clinical trial of regular, high-dose tetracosactide (ACTH1-24) in patients with autoimmune Addison's disease, we noted that four of nine premenopausal women in the study began to complain of menstrual disturbance (Gan et al., 2014).
To determine feasibility of this approach in clinical practice patients admitted with AECOPD were screened for participation in a trial of regular NIV assisted rehabilitation during their hospital admission.
Patients were recruited from a randomized clinical equivalence trial (CET) of regular cognitive-behavioral group therapy (gCBT) vs. internet-based CBT (iCBT) for PD [ 13](see additional file 1).
Although such rather costly and complicated investigations would provide high internal validity, the generalisability of findings from such trials to regular primary health care provision can sometimes be questioned [ 20].
In 27 patients in a treatment trial of SCLC, regular follow-up laboratory values were prospectively obtained.
Whilst NCRI members showed a preference for providing feedback after trial closure, the patient respondents were more likely to endorse the provision of results at the end of an individual's trial participation and/or a system of regular trial updates.
It is conceivable that participation in the trial, and receipt of regular voice and text messages, could have contributed to a risk of stigma for the participants; however, exploring this will require more in-depth qualitative studies.
There were 300 trials in total, split into 6 blocks of 50 trials (allowing regular periods of rest).
38 The publication of randomised trials demonstrating the ability of regular faecal occult blood testing (FOBT) to reduce the risk of death from colorectal cancer 39 40 was the starting point of FOBT based screening activities in several European countries (such as France and the UK).
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CEO of Professional Science Editing for Scientists @ prosciediting.com