The cued recall condition contained a total of 21 trials, with seven trials of each memory, presented in a pseudorandom order while ensuring that the same memory was not repeated two or more times in a row.
While behavioural trials of working memory (WM) training have received much attention in recent years, a lesser explored parallel approach is functional neuroimaging.
Specifically, averaged across trials of working memory tasks, neurons exhibit different firing rate patterns during the delay of those tasks.
Individual cells exhibit a significant amount of variability however, both in terms of firing frequency within and between trials of working memory tasks and may even exhibit different patterned behaviors from trial to trial [5].
However, the variability in patterned behavior and the firing statistics of real neurons across the entire range of those behaviors across and within trials of working memory tasks are typical not reproduced.
Notwithstanding the conceptual and practical difficulties, the time is perhaps right to consider controlled trials of drug memory reconsolidation blockade in a treatment setting, with the advantage that a clinically available medication could be used (propranolol or other β-adrenoceptor antagonist) in perhaps only one or few treatment sessions (Taylor et al., 2009; Milton & Everitt, 2010).
During go trials of our memory-based pursuit task, discharge modulation of this neuron during the action period was not significant except for a weak discharge during recentering saccades at the beginning of the reward period (Fig. 6 A 1).
In the ACTIVE clinical trial of cognitive memory and reasoning among older adults, researchers not only found improvement in cognitive abilities but also gains in mobility and health related quality of life [ 29].
We used five trials of the verbal memory recall (VMR) to assess learning and short-term memory.
Whole brain analysis showed that a variety of regions commonly associated with working memory maintenance (for review see [26]) were active when all delay periods on correct trials of associative working memory were compared to the baseline, indicating that our set-up was suitable to assess the brain regions involved in working memory maintenance.
