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Controlled trials of management of DFM are lacking [ 7, 12].
There is a paucity of clinical trials of management of obesity in patients with severe mental illness.
While antihypertensive drugs can have negative effects on specific dimensions of quality of life (such as sexual function), 25 large trials of management of hypertension have found either no overall effects on quality of life or modest gains.
4 5 No randomised trials of management strategies in new onset angina have been carried out, however, with most evidence derived from studies in patients with angiographic documentation of coronary artery disease or with previous myocardial infarction.
As admission to hospital in patients with stage 3-5 non-dialysis chronic kidney disease is usually because of comorbidity and because randomised trials of management of chronic kidney disease have not shown that interventions prevent admissions, we did not include the cost of admissions in our analysis.
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3331 women completed the POSM as part of baseline psychosocial assessment in a trial of management of low grade cervical cytological abnormalities.
To inform these management debates, a randomised controlled trial (TOMBOLA, trial of management of borderline and other low grade abnormal smears) was established in the late 1990s.
It may be noted that the DCCT was a trial of management and not of the impact of low HbA1c in isolation.
A UK trial of management of low-grade abnormalities detected on screening for cervical pre-cancer (TOMBOLA) provided EQ-5D data for over 3,000 women.
Over 3500 women recruited to TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears) participated in this study.
Subjects were women assessed for eligibility for TOMBOLA (Trial Of Management of Borderline and Other Low-grade Abnormal smears), a randomised controlled trial (RCT) of alternative management policies and HPV triage (TOMBOLA Group, 2006).
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