Third, a trial of initiation of prednisone 3 mg/day in patients who had never been treated previously with prednisone, rather than withdrawal from prednisone, might give more definitive information.
Before considering dedicated randomised clinical trials of clopidogrel initiation vs aspirin reinitiation among patients with ischaemic stroke, prospective cohort studies should explore this issue utilising more precise information on the underlying mechanism of the index stroke and treatment of post-stroke risk factors.
The CGM TIME Trial (Timing of Initiation of Continuous Glucose Monitoring in Established Pediatric Diabetes) was designed to test this hypothesis and launched as part of the newly created JDRF Canadian Clinical Trial Network JDRF CCTNN).
In essence, this substudy functioned like a randomized controlled trial of antiretroviral initiation at CD4 counts more than 350 cells/μL compared to deferral of therapy until CD4 counts were below 250 cells/μL.
The studies were conducted amongst staff and patients in South Africa during a randomised trial of nurse initiation of antiretroviral therapy (ART) and integration of HIV care into primary care services – the Streamlining Tasks and Roles to Expand Treatment and Care for HIV (STRETCH) trial.
Further trials of early NIPPV initiation in ALS patients are warranted, and supported from a cost-effectiveness perspective.
The data analyzed included year of trial initiation, use of PE regimen, maximal age of patients, proportion of patients with good PS, proportion of male patients, and definition of PCI settings.
Eligible studies selected were cohort and randomised trials that assessed timing of initiation of RRT in critically ill adults with AKI.
Fifty-eight (55%) trials were registered correctly according to ICMJE criteria (ie, before or at the time of initiation for trials conducted after 1 July 2005, and before 13 September 2005 for trials starting before 1 July 2005).
In four of the included trials, initiation of RRT immediately after randomization was defined as "early" [28, 33 35].
