Sentence examples for trials of good from inspiring English sources
Randomised, controlled trials of good quality are a recognised means to robustly assess the efficacy of interventions in clinical practice.
Results: Of the 180 cases surveyed, 123 (68.3%) (95% CI, 61.5%-75.1%) were based on clinical trials of good methodologic quality (Category I).
This systematic review will consider only randomised controlled trials of good quality.
The review included 11 trials of good quality that evaluated sitagliptin therapy with a total of 6,743 patients.
Review: Intravenous immunoglobulin for treating sepsis and septic shock Comparison: Polyclonal IVIG vs placebo or no intervention Outcome: All-cause mortality (ACM) A sensitivity analysis was also conducted, including only seven trials of good and fair quality.
These findings are reinforced by White et al [ 7], who discouraged further reviews on the subject, and argued instead that "the focus must be on actually conducting more clinical trials" of good quality, a view echoed by others in the field [ 6, 8- 10].
The included trials were of good methodological quality except for the trial by Yildirim et al. 27 Insufficient details were given to enable assessment of blinding at all levels.
Likewise and maybe more realistically, patient phenotypes not to be included in trials because of good prognosis or absence of ongoing infection should be identified (for instance, by excluding patients with normal values of procalcitonin).
Only one trial was of good quality, and the other nine trials were more or less well designed.
Although combining similar trials of sufficiently good quality increases the power and precision of the pooled estimate, the number of neonates in the included trials (2345) may not be large enough to allow much confidence to be placed in the apparently reassuring results associated with preoperative administration.
By comparison with other settings, the standard treatment in our trial was of good quality, and this could affect the external validity.
