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Trials of dose reducing led to attacks' recurrence.
The mathematical concepts and previous clinical trials of dose density that contributed to the design of CALGB 9741 will be reviewed.
We suggest that policymakers consider including trials of dose and frequency in vitamin A distribution programmes.
We suggest that other groups evaluate our algorithm and exclude poor prognosis patients from trials of dose intensification.
To guide design choices for future clinical trials of dose intensification in the adjuvant therapy of human breast cancer, we have developed a mathematical model to extract information regarding the natural history of breast cancers and their sensitivity to chemotherapy from clinical RFS curves.
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Trials of dose-dense chemotherapy were defined in this review as the same type and total amount of the drug administered over a shorter interval of time [ 25].
A systematic review of randomized controlled trials of dose-dense anthracycline-based chemotherapy in early breast cancer, comprising a meta-analysis that combined n = 1,310 patients, revealed that women who received a dose-dense chemotherapy regimen were not more likely to develop cardiotoxicity (OR = 0.5; 95 % CI = 0.05 5.54) [ 25].
Challenges and research priorities in this exciting research field are defined and a possible design for a randomized clinical trial of dose painting is presented.
This was a randomized, double-blinded, clinical trial of dose responses including placebo comparison, involving 13 dental facilities.
Upon hearing that his diuretics and sleeping pill may be contributing to his urinary symptoms, Mr. S. elects a trial of dose reduction and conservative management.
To report toxicity and early survival data for IDEAL-CRT, a trial of dose-escalated concurrent chemoradiotherapy (CRT) for non-small cell lung cancer.
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