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Table 3 summarizes the design and main findings of most of the randomized controlled trials of ART modification in virologically suppressed patients.
We used pooled data from 2 large African adult and pediatric trials of ART management strategies, in which mortality ascertainment was near complete.
Global functioning had not been assessed in randomised trials of Art Therapy for people with schizophrenia that had been completed when the study was being planned, so data on mean GAF scores and standard deviations were taken from previous trials of Compliance Therapy and Cognitive Therapy for people with schizophrenia.
As new ARVs with improved toxicity profiles have been developed, there have been an increasing number of clinical trials of ART modification in virologically suppressed patients, and many of these studies have been summarized in an excellent review by Van den Eynde and Podzamczer [ 11].
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Decreases in IL-6 and sVCAM-1 in this population of racial and ethnic minorities initiating ARV appear generally consistent with results noted in previous randomized clinical trials of ART-naïve patients.
The ANRS 116 trial was a prospective, open-label, multicentre trial of ART interruption in patients who had started treatment early (ClinicalTrials.gov Identifier, NCT00118677).
There has been no trial of ART cessation in management of IRIS.
We believe that this is the first large scale pragmatic trial of Art Therapy for people with schizophrenia.
In the first ever clinical trial of art therapy, the researchers studied 47 people with chronic mental illness of whom half had a diagnosis of schizophrenia.
Finally, in chronic pleocytosis without headache, a trial of ART may confirm HIV as the cause if the cell count resolves.
10 22 The DART study, the only other randomised controlled trial of ART monitoring in Africa, found improved clinical outcomes with CD4 compared with clinical monitoring after two years' receipt of ART.
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