We hope that our findings can be an inspiration for future trials of a larger scale.
Further prospective randomized placebo controlled trials of a larger patient group with delirium should be carried out to test the generalizability of our findings.
However, we believe that the true value of the INTERSEPT study is to serve as guide for future trials, including trials of a larger population of patients to validate the results of the present study.
Furthermore, in the phase III US Food and Drug Administration registration trial of a large molecular weight and high degree of substitution starch in the US, much larger doses than used in the present trial (upwards of 5,000 cc) were not associated with any renal dysfunction [ 8].
A clear limitation of pooling such a diverse set of trials, with a large degree of statistical heterogeneity, is the limited generalisability of the average treatment effects.
Meta-analyses typically include a limited number of trials: the median number of trials in a large sample of Cochrane meta- analyses was 3 [ 45].
The women's service is not yet broadly accessible – currently, a sign-up page allows women to enter in their email address if they want to participate in the early trials ahead of a larger launch planned for this fall.
Meta-analyses of randomized trials are a large share of this literature.
However, the results of clinical trials with a large panel of FTase inhibitors were disappointing and discouraged many from pursuing further efforts to target oncogenic Ras.
