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Reference memory is regarded as a long-term memory for information that remains constant over repeated trials (memory for the positions of baited arms), whereas working memory is considered a short-time memory in which the information to be remembered changes in every trial (memory for the positions of arms that had already been visited in each trial) [ 35, 36].
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It was found to interfere with single-trial memory acquisition in a delayed object recognition test, a spontaneous learning task that involves no appetitive or aversive motivator.
With a fearful experience, our survival systems kick into action, and we can achieve what's known as a single trial memory.
In the probe trial memory for the platform location was determined.
The following day, each mouse was subjected to a 20-trial memory test for the two-odorant task.
To overcome the above technical or experimental limitations, the present study employs the classic Pavlov fear conditioning paradigm, coupled with large-scale recording and decoding methods to investigate the real-time population-level activity patterns in the hippocampus in relation with trial-to-trial memory scores.
Ninety minutes following the last training trial a 60-s probe trial memory test was performed by removing the platform from the maze.
In monkeys, one-trial memory for object-place associations (similar to our current task) appears to be critically dependent not on hippocampus but on posterior parahippocampus (41).
3. Retention trial: Memory was evaluated 24 h post-training by returning the animals to the light compartment and recording their latency to enter the dark compartment (four paws in).
The following behaviours were scored: thigmotaxis (i.e., swimming along the pool border, a behaviour indicative of risk assessment), latency to reach the platform (acquisition phase); time spent in the acquisition quadrant compared with other quadrants (probe trial memory test).
The outcome measure used here was the 'first trial memory score' (FTMS), the number of patterns correctly associated to their locations in the first attempt summed across the stages completed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com