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Their prevalence in surgical trials mandates an approach to developing valid evidence for operations that directly addresses these unique problems.
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Protocols for these four of five pivotal phase 3 trials mandated that patients receiving a stable immunomodulator regimen at baseline would continue such use throughout study participation.
The trial mandates assessment of disease activity with monthly visits in the T2T intervention group and up to monthly treatment acceleration until disease control is achieved.
Thus the trial mandated 3 months of neoadjuvant 5FU/LV in the preoperative arm, followed by postoperative adjuvant weekly 5FU/LV.
69 A total of 21 105 patients with moderate to high risk non-valvular atrial fibrillation were randomized, and the trial mandated a dose reduction (by half) for patients with any of the following: creatinine clearance 30-50 mL/min; weight ≤60 kg; or concomitant use of verapamil, quinidine, or dronedarone.
Establishing the diagnosis of PC remains a significant clinical problem that delays initiation of therapy, impacts enrollment in clinical trials, and mandates that patients undergo major surgical procedures in the absence of definitive findings.
Parliament also passed on Thursday a tough new anti-rape law intended to speed up trials and mandating DNA testing – another proposal that has troubled some religious hardliners in the past who say Sharia law says rape can only be proved by testimony of multiple eyewitnesses.
Further large-scale trials appear mandated.
Recent large prospective trials would mandate caution when using β-blockers in acute settings of hemodynamic compromise.
The ESPAC-3 and European Organization for the Research and Treatment of Cancer (EORTC) 40013 postoperative trials both mandated the acquisition of high-quality preoperative imaging, but did not require adherence to a standardized definition of resectability.
The shark cartilage clinical trial was mandated by Congress and was sponsored by the National Cancer Institute.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com