The outcomes of the two Phase I trials justify moving forward with the assessment of these two agents.
The belimumab in patients with pSS BELISS trials justify future studies with the BAFF-targeting drug in the autoantibody-positive subset of pSS [ 39, 40].
DSMB members will be asked to give advice on whether the accumulated safety data − notably SAEs − from the trial, together with results from other relevant trials, justify continuing recruitment of further patients.
The prosecutor's conclusion that "neither the investigation nor the trial justified the charges against Mr Strauss-Kahn" brings the proceedings to an abrupt and unexpected end.
Although of limited small size, this trial justified the concept of targeting prolactin as a novel therapeutic strategy for PPCM and provided the rationale for a larger randomized and controlled clinical trial with bromocriptine (Table 1).
Sen. Joel Anderson (R-San Diego) said the delay in the trial justifies immediate action by the Senate to expel Calderon, who the chamber had put on indefinite paid suspension in March.
Further trials are justified for a detailed evaluation of abdominal NPT indications.
25 Further randomised controlled trials are justified.
Larger trials are justified to explore effects on patient-centred outcomes.
Surgical trials are justified by equipoise not only when there is uncertainty about pure benefit, but also when there is uncertainty about whether benefit outweighs harms.
