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Successful randomisation in surgical trials is straightforward where the stakes are low and the clinical community is either in genuine equipoise or largely favourable to the new treatment.
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The (frequentist) analysis of response rate from the Phase II trial is straightforward in that the number of responses observed, r, is divided by the number of patients recruited, N. Thus the observed response rate is which is an estimate of the true population response rate θ.
31– 33 Comparing results from these trials is not straightforward because they employed different designs and comparators.
The design, analysis and interpretation of non-inferiority trials is not straightforward and a critical article on these issues is welcomed.
The addition of a lapse parameter to the working memory models outlined is straightforward; on every trial, participants pay attention to the task at hand with a probability of Z. 1 If the participants lapse, they encode no items and guess "change" with a probability of G.
Measuring PA is straightforward and could easily be integrated into interventional exercise trials.
The science is straightforward.
She is straightforward.
My implementation is straightforward.
The point is straightforward.
The method is straightforward.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com