Exact(13)
Determining the benefits of a screening test is complex, particularly when information from randomized trials is lacking.
However, robust evidence from large randomized, controlled trials is lacking.
However evidence in realistic situations, where one trial might be much larger than the other trials, is lacking.
Although preclinical models have shown promising results, evidence for their efficacy in large-scale randomized controlled trials is lacking.
Since conclusive evidence from randomised trials is lacking, the clinical benefit of helmet therapy compared with the natural course of skull deformation remains unknown.
14 15 In large cohort studies, renal decline was slower in those with greater water inake, 16 18 but evidence from clinical trials is lacking.
Similar(47)
One recent scientific review concluded that there was some evidence suggesting it could have a role, but the gold standard of proof necessary for confirmation and further evaluation – randomised clinical trials – were lacking.
However, human trials are lacking.
However, data from randomized trials are lacking.
A variety of endoscopic techniques have been proposed, but controlled prospective trials are lacking.
N-of-1 trials are a unique trial design which can inform personalized evidence-based decisions for the patient when data from traditional clinical trials are lacking or not generalizable.
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